Download PDF by Moshe S. Razzaque: Fibrogenesis: Cellular and Molecular Basis (Medical

By Moshe S. Razzaque

ISBN-10: 0306478617

ISBN-13: 9780306478611

Fibrogenesis: mobile and Molecular foundation is the 1st quantity to supply a synopsis of the swift growth that has been documented in fibrogenesis over final couple of years, which considerably more desirable our knowing of the pathomechanisms of fibrotic illnesses. wisdom on molecular and celluar foundation of fibrotic illnesses has supplied possibilities to strengthen selective and potent gene-based healing techniques. The chapters during this ebook were chosen to supply accomplished info on fibrogenesis, which isn't restricted to any particular organ. person chapters current mechanisms of fibrotic illnesses regarding lung, liver, kidney, middle, blood vessels, and extra. The relevance and value of inflammatory cytokines, chemokines, transcriptional components, fibrogenic molecules, signaling cascade, and matrix home improvement in fibrogenesis are defined extensive, offering the reader with current and up-to-date details.

Show description

Read or Download Fibrogenesis: Cellular and Molecular Basis (Medical Intelligence Unit) PDF

Best molecular biology books

Download PDF by Daniel Herschlag: Biophysical, Chemical, and Functional Probes of RNA

This MIE quantity offers laboratory suggestions that target to foretell the constitution of a protein which may have great implications starting from drug layout, to mobile pathways and their dynamics, to viral access into cells. specialist researchers introduce the main complex applied sciences and methods in protein constitution and foldingIncludes suggestions on tiling assays.

Download e-book for iPad: Mythos Determinismus: Wieviel erklart uns die Hirnforschung? by Brigitte Falkenburg

Aus der Sicht der Neurobiologie regiert im Kopf das neuronale Geschehen. Doch was once wissen die Hirnforscher genau über die Mechanismen des Hirngeschehens und ihren Einfluss auf den menschlichen Geist? Dieser Frage geht Brigitte Falkenburg nach. Die Physik hat sich längst vom mechanistischen Weltbild gelöst, in der Neurobiologie bleiben überholte mechanistische Vorstellungen bis heute wirksam.

Download e-book for iPad: Membrane Protein – Lipid Interactions: Physics and Chemistry by Jordi H. Borrell, Òscar Domènech, Kevin M.W. Keough

This e-book has been conceives as a quick creation to biomembranes actual chemistry for undergraduate scholars of sciences, and it really is really devoted to the lipid-protein membrane interactions. A normal advent is gifted in Chapters 1 and a pair of. the subsequent Chapters, three and four, describe the main approved theories on lipid-membrane protein interactions in addition to the hot experimental ways, specifically, those arose from nano sciences as atomic for microscopy and unmarried molecule strength spectroscopy.

Download e-book for iPad: The Calculus of Life: Towards a Theory of Life by Andrés Moya

This publication explores the interesting global of theoretical biology and is split into 3 sections. the 1st part examines the jobs performed by way of popular scientists comparable to Jacob, Monod, Rosen, Turing, von Bertalanffy, Waddington and Woodger in constructing the sector of theoretical biology. the second one part, aided with various examples, helps the concept good judgment and computing are compatible formal languages to explain and comprehend organic phenomena.

Extra resources for Fibrogenesis: Cellular and Molecular Basis (Medical Intelligence Unit)

Sample text

Ohashi R, Shimizu A, Masuda Y et al. Peritubular capillary regression during the progression of experimental obstructive nephropathy. J Am Soc Nephrol 2002; 13:1795-805. 13. Imasawa T , Utsunomiya Y, Kawamura T et al. The potential of bone marrow-derived cells to differentiate to glomerular mesangial cells. J Am Soc Nephrol 2 0 0 1 ; 12:1401-1409. 14. Ito T , Suzuki A, Imai E et al. Bone marrow is a reservoir of repopulating mesangial cells during glomerular remodeling. J Am Soc Nephrol 2001; 12:2625-2635.

It is likely that MIP-lOC plays a significant role in crescentic glomerulonephritis, by recruiting and activating macrophages and T cells. Measurement of urinary levels of MIP-la appears to be clinically useful as its level correlates with disease activity of human crescentic glomerulonephritis. Recent studies have documented the beneficial effects of neutralizing antibodies and specific chemokine/chemokine receptor antagonists in crescentic glomerulonephritis. Anti-MCP-1 or anti- MIP-la antibodies or MCP-1 deficiency resulted in less glomerular accumulation of macrophages, reduced crescent formation, decreased interstitial damage, and most importantly, less proteinuria.

Recendy, the beneficial effects of Y-27632, a specific Rho-associated coiled-coil forming protein kinase (ROCK) inhibitor, were studied using the unilateral ureteral obstruction model. In vivo studies have shown that Y-27632 treatment resulted in less alpha smooth muscle actin-positive cells, reduced numbers and expression of macrophages, MCP-1, TGF-P and OC (I) collagen, and resulted in less interstitial fibrotic changes, in the unilateral ureteral obstruction model. ^^ Effectiveness of Anti-Chemokine/Cytokine Therapy and Its Possible Therapeutic Implications in Renal Diseases Agents that influence cAMP^^ or N F - K B , such as antioxidants, glucocorticoids and aspirin, can modulate the expression of chemokines/cytokines and improve renal pathology.

Download PDF sample

Fibrogenesis: Cellular and Molecular Basis (Medical Intelligence Unit) by Moshe S. Razzaque

by Mark

Rated 4.45 of 5 – based on 49 votes