By Moshe S. Razzaque
Fibrogenesis: mobile and Molecular foundation is the 1st quantity to supply a synopsis of the swift growth that has been documented in fibrogenesis over final couple of years, which considerably more desirable our knowing of the pathomechanisms of fibrotic illnesses. wisdom on molecular and celluar foundation of fibrotic illnesses has supplied possibilities to strengthen selective and potent gene-based healing techniques. The chapters during this ebook were chosen to supply accomplished info on fibrogenesis, which isn't restricted to any particular organ. person chapters current mechanisms of fibrotic illnesses regarding lung, liver, kidney, middle, blood vessels, and extra. The relevance and value of inflammatory cytokines, chemokines, transcriptional components, fibrogenic molecules, signaling cascade, and matrix home improvement in fibrogenesis are defined extensive, offering the reader with current and up-to-date details.
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Extra resources for Fibrogenesis: Cellular and Molecular Basis (Medical Intelligence Unit)
Ohashi R, Shimizu A, Masuda Y et al. Peritubular capillary regression during the progression of experimental obstructive nephropathy. J Am Soc Nephrol 2002; 13:1795-805. 13. Imasawa T , Utsunomiya Y, Kawamura T et al. The potential of bone marrow-derived cells to differentiate to glomerular mesangial cells. J Am Soc Nephrol 2 0 0 1 ; 12:1401-1409. 14. Ito T , Suzuki A, Imai E et al. Bone marrow is a reservoir of repopulating mesangial cells during glomerular remodeling. J Am Soc Nephrol 2001; 12:2625-2635.
It is likely that MIP-lOC plays a significant role in crescentic glomerulonephritis, by recruiting and activating macrophages and T cells. Measurement of urinary levels of MIP-la appears to be clinically useful as its level correlates with disease activity of human crescentic glomerulonephritis. Recent studies have documented the beneficial effects of neutralizing antibodies and specific chemokine/chemokine receptor antagonists in crescentic glomerulonephritis. Anti-MCP-1 or anti- MIP-la antibodies or MCP-1 deficiency resulted in less glomerular accumulation of macrophages, reduced crescent formation, decreased interstitial damage, and most importantly, less proteinuria.
Recendy, the beneficial effects of Y-27632, a specific Rho-associated coiled-coil forming protein kinase (ROCK) inhibitor, were studied using the unilateral ureteral obstruction model. In vivo studies have shown that Y-27632 treatment resulted in less alpha smooth muscle actin-positive cells, reduced numbers and expression of macrophages, MCP-1, TGF-P and OC (I) collagen, and resulted in less interstitial fibrotic changes, in the unilateral ureteral obstruction model. ^^ Effectiveness of Anti-Chemokine/Cytokine Therapy and Its Possible Therapeutic Implications in Renal Diseases Agents that influence cAMP^^ or N F - K B , such as antioxidants, glucocorticoids and aspirin, can modulate the expression of chemokines/cytokines and improve renal pathology.
Fibrogenesis: Cellular and Molecular Basis (Medical Intelligence Unit) by Moshe S. Razzaque